Thermaltake Level 20 HT Snow edition Full Tower PC Case Tempered Glass/Single or Dual Loop/Water Cooling/Up to EATX, CA-1P6-00F6WN-00

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HJ (Iran) and HT (Cameroon) v Secretary of State for the Home Department [2010] UKSC 31 7 July 2010

Benvenga, S. et al. Type of fish consumed and thyroid autoimmunity in pregnancy and postpartum. Endocrine 52, 120–129. https://doi.org/10.1007/s12020-015-0698-3 (2016). Zimmermann, M. B. & Kohrle, J. The impact of iron and selenium deficiencies on iodine and thyroid metabolism: Biochemistry and relevance to public health. Thyroid 12, 867–878. https://doi.org/10.1089/105072502761016494 (2002). Calder, P. C. Omega-3 fatty acids and inflammatory processes: From molecules to man. Biochem. Soc. Trans. 45, 1105–1115. https://doi.org/10.1042/bst20160474 (2017).

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Name of case: R (on the application of HM and MA and KH) v Secretary of State for the Home Department The claimants sought judicial review of the Home Office’s MPE policy and practice, on the following grounds:

Kolcic, I. et al. Mediterranean diet in the southern Croatia—does it still exist?. Croat. Med. J. 57, 415–424 (2016).We also investigated if two sub-groups of HT patients (depending on LT4 therapy) differ in dietary habits, as this analysis is important for data interpretation. The rationale behind this analysis was to take into consideration possible changes in diet between these two sub-groups (for example, HT patients who were taking LT4 therapy might have changed dietary habits upon disease diagnosis) which could introduce spurious associations for our main case–control analysis. We used a logistic regression model, where therapy status (with/without LT4 therapy) was used as the dependent variable and 22 food groups as independent variables, along with age and gender. High iodine intake (median urinary iodine concentration ≥ 300 μg/L) 7, especially in areas with sufficient iodine supply, is one of the most known factors that increase the incidence of HT 8. Also, low vitamin D levels (below 30 ng/mL) 9 and low selenium intake (bellow 40 µg/day) 10 are proposed to be risk factors for HT development, albeit a role of these factors in HT still needs to be confirmed. Conversely, alcohol intake was proposed to decrease the risk for HT 11. Other dietary factors are also considered as potential environmental modifiers of the clinical appearance of HT 12, 13, 14, 15. A diet low in gluten has been recently proposed to have beneficial effects on the disease course in a study of 34 women with HT 13. Another study of 83 patients with HT indicated that restriction of lactose intake in lactose-intolerant HT patients resulted with decreased thyroid-stimulating hormone (TSH) levels 14. However, the current knowledge of this topic is scarce and only the following two studies analyzed the association between thyroid function and dietary factors using food frequency questionnaire (FFQ) as an assessment tool to date. A large population-based study of 65,981 participants found an association of the vegan diet with a lower risk of self-reported hypothyroidism 16. Another recent study showed that higher animal fat and butter intake are associated with the risk of positivity to TPOAb and/or TgAb antibodies using 1,887 participants, whereas diet rich in vegetables, dried fruit, nuts and muesli consumption decreased that risk 17. Perona, J. S. et al. Virgin olive oil reduces blood pressure in hypertensive elderly subjects. Clin. Nutr. (Edinburgh, Scotland) 23, 1113–1121. https://doi.org/10.1016/j.clnu.2004.02.004 (2004). Honikel, K. O. The use and control of nitrate and nitrite for the processing of meat products. Meat Sci. 78, 68–76. https://doi.org/10.1016/j.meatsci.2007.05.030 (2008).

Brcic, L. et al. Genome-wide association analysis suggests novel loci for Hashimoto’s thyroiditis. J. Endocrinol. Invest. 42, 567–576. https://doi.org/10.1007/s40618-018-0955-4 (2019). Ferguson, L. R. Meat and cancer. Meat. Sci. 84, 308–313. https://doi.org/10.1016/j.meatsci.2009.06.032 (2010). Matana, A. et al. Dietary factors associated with plasma thyroid peroxidase and thyroglobulin antibodies. Nutrients 9, 5 (2017). Finally, beside already mentioned beneficial roles of vitamins, minerals and dietary fibers, fruits additionally contain phytochemicals such as polyphenolic compounds that are known for their anti-inflammatory and antioxidant effects on human health 64. Dietary recommendations

Bahadoran, Z. et al. Is dietary nitrate/nitrite exposure a risk factor for development of thyroid abnormality? A systematic review and meta-analysis. Nitric Oxide Biol. Chem. 47, 65–76. https://doi.org/10.1016/j.niox.2015.04.002 (2015). The Hot Case is based on the appearance of the fictional criminal Carmen Sandiego, who sported a very similar getup throughout most iterations. Calder, P. C. & Yaqoob, P. Omega-3 polyunsaturated fatty acids and human health outcomes. BioFactors (Oxford, England) 35, 266–272. https://doi.org/10.1002/biof.42 (2009).